ALVR108: An allogeneic, off-the-shelf virus-specific T cell (VST) therapy targeting Human Herpesvirus-8

ALVR108

Serious Diseases Associate with Human Herpesvirus-8

HHV-8 is a herpesvirus that establishes life-long latency after primary infection. Though primary HHV-8 infection is usually asymptomatic, reactivation in immunocompromised individuals, such as those infected with human immunodeficiency virus, or HIV, or transplant recipients.

Reactivated Infections

A reactivated HHV-8 infection can result in a range of serious diseases, including Kaposi Sarcoma (KS), primary effusion lymphoma (PEL), and multi-centric Castleman’s disease (MCD). These diseases each lack effective standard of care treatments that can have a meaningful benefit for patients.

Development Plan

Preclinical data demonstrated that ALVR108 has potent antiviral activity against HHPV-8. ALVR108 may be provided to patients who are at risk of developing KS, PEL, or MCD.

The seroprevalence of human herpesvirus-8 is estimated to be between 1-5% in the United States, 10-20% in certain Mediterranean countries, and 30-80% in parts of sub-Saharan Africa.

Our Pipeline

Our allogeneic, off-the-shelf VST therapy candidates target 12 different devastating viruses to treat and prevent life-threatening viral diseases.
View

Expanded Access

Read our expanded access policy.
View

AlloVir is the Global Leader in Developing VST Immunotherapies

We develop highly innovative allogeneic, off-the-shelf VST therapy candidates designed to treat or prevent devastating viral infections and diseases.

Our Pipeline

Our allogeneic, off-the-shelf, VST therapy candidates target 12 different devastating viruses to treat or prevent life-threatening viral diseases.
view

Our Platform

Our proprietary platform develops allogeneic, off-the-shelf VSTs designed to restore immunity in patients with T cell deficiencies.
learn

Our People

Our founders have a singular vision: to serve patients at risk of the devastating consequences of severe viral infections and diseases.
meet
AlloVir does not control and is not responsible for the content on the website you are about to visit. AlloVir is providing this link as a convenience, and this link does not imply AlloVir’s endorsement of any material on the website you are about to visit. Do you wish to continue?
AlloVir does not control and is not responsible for the content on the website you are about to visit. AlloVir is providing this link as a convenience, and this link does not imply AlloVir’s endorsement of any material on the website you are about to visit. Do you wish to continue?