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Our Pipeline

A Deep Pipeline of Allogeneic, Off-The-Shelf, Virus-Specific T Cell (VST) Therapies

A large number of patients are fighting viral infections or diseases with limited or no treatment options. To address this, we are advancing a pipeline of allogeneic, off-the-shelf VSTs to treat or prevent life-threatening viral diseases.
Posoleucel (Viralym-M, ALVR105)
Multi-VSTs targeting BK Virus (BKV), Cytomegalovirus (CMV), Adenovirus (AdV), Epstein-Barr (EBV), and Human Herpesvirus-6 (HHV-6)
Target Indication
Target Population
Preclinical
POC Trial (Phase 1b/2)
Pivotal Trial (Phase 3)
Treatment of Virus-Associated Hemorrhagic-Cystitis
Allo-HSCT
Treatment of CMV
Allo-HSCT
Treatment of ADV
Allo-HSCT
Prevention of BKV, CMV, AdV, EBV, HHV-6 and JCV
Allo-HSCT
Treatment of BKV
Kidney Transplant
Treatment of CMV
Solid Organ Transplant
Posoleucel (Viralym-M, ALVR105)
Multi-VSTs targeting BK Virus (BKV), Cytomegalovirus (CMV), Adenovirus (AdV), Epstein-Barr (EBV), and Human Herpesvirus-6 (HHV-6)
Target Indication
Target Population
Preclinical
POC Trial (Phase 1b/2)
Pivotal Trial (Phase 3)
Treatment of Virus-Associated Hemorrhagic-Cystitis
Allo-HSCT
Treatment of CMV
Allo-HSCT
Treatment of ADV
Allo-HSCT
Prevention of BKV, CMV, AdV, EBV, HHV-6 and JCV
Allo-HSCT
BKV Pre-emptive Treatment in KT
Kidney Transplant
Treatment of CMV
Solid Organ Transplant
ALVR106
Multi-VSTs targeting Respiratory syncytial virus (RSV), Influenza, Parainfluenza Virus (PIV), and Human Metapneumovirus (hMPV)
Target Indication
Target Population
Preclinical
POC Trial (Phase 1b/2)
Pivotal Trial (Phase 3)
Treatment of RSV, Influenza, PIV, & hMPV
Allo-/Auto-HSCT
IND Cleared in Q4 2020
Treatment of RSV, Influenza, PIV, & hMPV
High-risk general population*
ALVR109
Single-VST targeting SARS-CoV-2
Target Indication
Target Population
Preclinical
POC Trial (Phase 1b/2)
Pivotal Trial (Phase 3)
Treatment of COVID-19
High-risk general population*
ALVR107
Single-VST targeting Hepatitis B (HBV)
Target Indication
Target Population
Preclinical
POC Trial (Phase 1b/2)
Pivotal Trial (Phase 3)
Treatment of HBV
Patients with chronic HBV
ALVR108
Single-VST targeting Human Herpesvirus-8 (HHV-8)
Target Indication
Target Population
Preclinical
POC Trial (Phase 1b/2)
Pivotal Trial (Phase 3)
Treatment of HHV-8
Patients with KS, MCD, or PEL
Definitions
Allo-HSCT: allogeneic HSCT; Auto-HSCT: autologous HSCT; KS: Kaposi Sarcoma; MCD: Multi-centric Castleman Disease; PEL: Primary Effusion Lymphoma; POC: Proof-of-concept; High-risk general population: immunocompromised cancer patients, the elderly, and very young
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We Treat Individuals at High Risk

Our allogeneic, off-the-shelf VST candidates benefit patients with T cell deficiencies, including transplant recipients, immunocompromised cancer patients, the elderly, and the very young, who are at a higher risk of the devastating consequences of viral diseases.
Life-Threatening Viral Infections
Uncontrolled Viral Diseases Cause End-Organ Damage and Mortality
BK Virus
Cytomegalovirus
Adenovirus
Epstein-Bar Virus
Human Herpesvirus-6
Parainfluenza Virus
Human Metapneumovirus
Influenza Virus
Respiratory Syncytial Virus
SARS-CoV-2
Hepatitis B Virus
Human Herpesvirus-8
Bladder
Severe hemorrhagic cystitis
Urinary obstruction
Cystectomy
Brain
Severe encephalitis
Seizure
Memory defect
Progressive Multifocal Leukoencephalopathy
Kidneys
Nephritis
Acute/chronic renal failure
End stage renal disease
Lungs
Pneumonia
Bronchitis
Respiratory failure
Eyes
Retinitis
Blindness
Liver
Chronic hepatitis
Liver cirrhosis
Hepatocellular Carcinoma
Small/Large Intestine
Colitis
Ulceration / perforation
Intestinal bleeding
Malignancy
Kaposi sarcoma
Primary Effusion
Lymphoma (PEL)

AlloVir is the global leader in developing VST immunotherapies

We develop highly innovative, allogeneic, off-the-shelf, virus-specific T cell (VST) therapies designed to prevent and treat life-threatening viral diseases.

Our Pipeline

Our allogeneic, off-the-shelf VST therapy candidates target 12 different devastating viruses as treatment or prevention.
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Our Platform

Our proprietary platform develops allogeneic, off-the-shelf VSTs designed to restore immunity in patients with T cell deficiencies.
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Our People

We are united in purpose around a singular mission to prevent and defeat life-threatening viral diseases.
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1100 Winter Street
Waltham, MA 02451

Cambridge

139 Main Street
Suite 500
Cambridge, MA 02142

Houston

Kirby Grove
2925 Richmond Ave, Suite 1200
Houston, TX 77098

Company

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