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Our Pipeline

A Deep Pipeline of Allogeneic, Off-The-Shelf, Virus-Specific T Cell (VST) Therapies

A large number of patients are fighting viral infections or diseases with limited or no treatment options. To address this, we are advancing a pipeline of allogeneic, off-the-shelf VSTs to treat or prevent life-threatening viral diseases.
Posoleucel (Viralym-M, ALVR105)
*Prevention of adenovirus (AdV), BK virus (BKV), cytomegalovirus (CMV), Epstein-Barr virus (EBV), human herpesvirus 6 (HHV-6), JC virus (JCV).
Target Population
Target Indication
Preclinical
POC Trial
(Phase 1b/2)
Pivotal Trial
(Phase 3)
Allo-HSCT
Treatment of vHC
Allo-HSCT
Treatment of AdV
Allo-HSCT
Multi-virus Prevention*
Kidney Transplant
Treatment of BKV
Solid Organ Transplant
Multi-virus Prevention*
ALVR106
Multi-VSTs targeting Human Metapneumovirus (hMPV), Influenza (Flu), Parainfluenza Virus (PIV), and Respiratory syncytial virus (RSV).
*High-risk general population: immunocompromised cancer patients, the elderly, and very young.
Target Population
Target Indication
Preclinical
POC Trial
(Phase 1b/2)
Pivotal Trial
(Phase 3)
Allo-/Auto-HSCT
Treatment of hMPV,
Flu, PIV, RSV
High-risk general
population*
Treatment of hMPV,
Flu, PIV, RSV
ALVR107
Single-VST targeting Hepatitis B (HBV).
Target Population
Target Indication
Preclinical
POC Trial
(Phase 1b/2)
Pivotal Trial
(Phase 3)
Chronic HBV
HBV Cure
ALVR109
Single-VST targeting SARS-CoV-2.
Target Population
Target Indication
Preclinical
POC Trial
(Phase 1b/2)
Pivotal Trial
(Phase 3)
Immunocompromised
Immuno-
compromised
COVID-19 Treatment
Compassionate
Use Access
Definitions
Allo-HSCT: allogeneic HSCT; Auto-HSCT: autologous HSCT; POC: Proof-of-concept; High-risk general population: immunocompromised cancer patients, the elderly, and very young.
Expanded Access

We Treat Individuals at High Risk

Our allogeneic, off-the-shelf VST candidates benefit patients with T cell deficiencies, including transplant recipients, immunocompromised cancer patients, the elderly, and the very young, who are at a higher risk of the devastating consequences of viral diseases.
Life-Threatening Viral Infections
Uncontrolled Viral Diseases Cause End-Organ Damage and Mortality
BK Virus
Cytomegalovirus
Adenovirus
Epstein-Barr Virus
Human Herpesvirus-6
Parainfluenza Virus
Human Metapneumovirus
Influenza Virus
Respiratory Syncytial Virus
SARS-CoV-2
Hepatitis B Virus
Bladder
Severe hemorrhagic cystitis
Urinary obstruction
Cystectomy
Brain
Severe encephalitis
Seizure
Memory defect
Progressive Multifocal Leukoencephalopathy
Kidneys
Nephritis
Acute/chronic renal failure
End stage renal disease
Lungs
Pneumonia
Bronchitis
Respiratory failure
Eyes
Retinitis
Blindness
Liver
Chronic hepatitis
Liver cirrhosis
Hepatocellular Carcinoma
Small/Large Intestine
Colitis
Ulceration / perforation
Intestinal bleeding
Malignancy
Kaposi sarcoma
Primary Effusion
Lymphoma (PEL)

AlloVir is the global leader in developing VST immunotherapies

We develop highly innovative, allogeneic, off-the-shelf, virus-specific T cell (VST) therapies designed to prevent and treat life-threatening viral diseases.

Our Pipeline

Our allogeneic, off-the-shelf VST therapy candidates target 12 different devastating viruses as treatment or prevention.
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Our Platform

Our proprietary platform develops allogeneic, off-the-shelf VSTs designed to restore immunity in patients with T cell deficiencies.
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Our People

We are united in purpose around a singular mission to prevent and defeat life-threatening viral diseases.
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Waltham HQ

1100 Winter Street
Waltham, MA 02451

Houston

Kirby Grove
2925 Richmond Ave, Suite 1200
Houston, TX 77098

Company

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