Posoleucel

Posoleucel (Viralym-M, ALVR105): A multi-virus specific T cell therapy (VST) targeting six devastating viruses

Posoleucel targets six devastating viral pathogens: adenovirus (AdV), BK virus (BKV), cytomegalovirus (CMV), Epstein-Barr virus (EBV), human herpesvirus 6 (HHV-6), and JC virus (JCV).

Life-threatening viral infections and diseases post transplantation

The immune systems of individuals undergoing potentially life-saving transplantations – the two most common types of which are allogeneic hematopoietic cell transplant (HCT) and solid organ transplant (SOT) – are suppressed or eliminated to prevent rejection of the transplanted cells or organs, leaving the patient highly prone to devastating viral infections or diseases, which can cause end-organ damage and mortality.

Allogeneic HCT conditioning regimens often require the complete elimination of a patient’s own stem cells, leaving patients without a functioning immune system and in a severely immunocompromised state post HCT. For 90% of allogeneic HCT patients, their suppressed immune system allows viruses that were previously in a latent state to reactivate, with more than 60% of HCT patients experiencing reactivation of more than one potentially fatal virus.


Currently, there are limited therapies for most viral infections in the post-transplant setting. The standard of care treatments have limited efficacy and are associated with significant toxicity.

Restoring Immunity with Posoleucel (Viralym-M, ALVR105)

Posoleucel is designed to restore T cell immunity in patients during the time of severe immune compromise between conditioning and reconstitution of patients’ immune systems.

Posoleucel is Designed to Treat and Prevent Viral Diseases Until the Patient’s Own Immune System Recovers

(a) Post 100 day data for proportion of patients with viral detection is from Huang, et al., as Hill et al. only measured out to 100 days. 1. Kedia et al., J Stem Cell Res Ther 2013. 2. Ison, Hirsch. Clin Microbiol Rev. 2019. 3. Hill et al, Blood 2017. 4. Huang et al, Biol Blood Marrow Trans 2017. 5. Stern L et al. Front Immunol. 2018;9:1-18. 6. Hill CID 2018.
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AlloVir does not control and is not responsible for the content on the website you are about to visit. AlloVir is providing this link as a convenience, and this link does not imply AlloVir’s endorsement of any material on the website you are about to visit. Do you wish to continue?