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VST Platform
Innovative science
Viral infections can be life-threatening for immunocompromised patients and in most cases, there are no effective treatment options.
There is an urgent need for therapies to treat and prevent these devastating viral infections and diseases in vulnerable patient populations with immune deficiencies, such as transplant recipients, cancer patients receiving chemotherapy, the elderly and the very young.
AlloVir is developing revolutionary, allogeneic, off-the-shelf, virus-specific
T cell (VST) therapies for immunocompromised patients fighting viral infections.
There is an urgent need for therapies to treat and prevent these devastating viral infections and diseases in vulnerable patient populations with immune deficiencies, such as transplant recipients, cancer patients receiving chemotherapy, the elderly and the very young.
AlloVir is developing revolutionary, allogeneic, off-the-shelf, virus-specific
T cell (VST) therapies for immunocompromised patients fighting viral infections.
Restoring Immunity
AlloVir’s investigational therapies aim to restore viral immunity in immunocompromised patients through the adoptive transfer of VSTs. Our cells have been prospectively generated from healthy, eligible donors, and as off-the-shelf therapies, they are immediately available for patients with T-cell deficiencies, who are at risk from the life-threatening consequences of viral diseases.
AlloVir’s Proprietary, Highly Efficient and Industrialized Platform Provides Key Advantages
Our Patented and Highly Efficient Platform Delivers Rapid, Scalable, Off-the-Shelf VST Therapy
Key Advantages
- Rationally designed cell bank, facilitating availability of VSTs covering >95% of patients
- Our VST platform minimizes antigen competition, enabling retention of VST diversity and polyclonality
- VST potency confirmed against individual target viruses using functional assay
- Simple and robust manufacturing yields hundreds of VST doses from a single donor/production run
- Our VSTs have long-term stability, supporting on-demand, broad availability for patients
The heroic role of T cells fighting viral infections
In healthy individuals, T cells from the body’s natural defense system provide protection against devastating viruses. For patients with T cell deficiencies, viruses may be uncontrolled, leading to potentially devastating and life-threatening consequences.
Virus-Specific T Cells Play a Central Role in Response to Viral Infection
Adaptive Cellular Immune Response in a Healthy Individual: Virus-specific T cell responses are vital components in cellular immunity against devastating viruses.
Developing an immune system outside the body
T cells from healthy patients with the right characteristics are activated, expanded and preserved for use on patients in need.
